Abstract

Daniel Belluscio

Here we present data on the utility of hCG Human Choriogonadotropin + diet in patients displaying one or more of the following clinical symptoms or laboratory findings: high blood pressure, diabetes type 2, hyperglycemia, hypertriglyceridemia, hypercholesterolemia, and gout as part of the metabolic syndrome. Introduction Metabolic Syndrome (MS), also known as plurimetabolic syndrome, insulin-resistant syndrome, or syndrome X, is a clinical entity with broad phenotypic variations. Individuals with an endogenous predisposition to it as genetically determined and conditioned by environmental factors. Typically, MS display insulin resistance and compensatory hyperinsulinemia associated with metabolic disorders, high blood pressure, hypertriglyceridemia, decreased HDLC. The presence of elevated LDL, increased free fatty acids plasmatic levels, postprandial lipemia and obesity, resulting in an increase in morbidity and mortality. MS is the aggregate of the most dangerous heart-risk factors, i.e., diabetes and pre-diabetes, abdominal obesity, changes in cholesterol rate, and high blood pressure. Although 80% of the nearly 200 million diabetic adults worldwide will die due to heart disease, MS subjects are also in a greater-risk stage. They are twice as potential sufferers of heart arrest or heart attack as the rest of the persons who do not suffer this syndrome. Laboratory and physical signs characteristic to MS:- Men Women Abdominal obesity (waist circumference) > 102cm > 88cm Triglycerides �?� 150mg/dl �?� 150mg/dl hypercholesterolemia) < 40mg/dl < 50mg/dl Blood pressure �?� 130 / �?� 85mmHg �?� 130 / �?� 85mmHg Fast glycemia �?� 110mg/dl �?� 110mg/dl MS triples the risk for heart disease (up to 80% of MS patients die because of complications of heart disease.) Prediction of MS evolution Average follow up for 8.9 years showed that mortality due to heart disease increased separately in 45% of men and 73% of women with MS. MS total mortality relative risk was 27% in men and 25% in women. Therefore, there is an urgent need to use medical treatment to improve life quality in these patients. The hCG Protocol MS treatment The utility of Human Chorionic Gonadotropin oral or injectable coupled to a very low-calorie diet for a short period for the treatment of MS, performed under precise control and follow-up protocol , improves the following parameters: 1) hypertriglyceridemia 2) Hypertension 3) Hypertriglyceridemia 4) Abdominal obesity 5) Sleep apnea Daily doses of Gonadotropin are adjusted depending on the BMI (Body Mass Index) to 300-600 International Units per day for oral administration. Moreover, they undergo a very low-calorie diet (about 500 Kcal/day) that is also low-fat, hypohydrocarbonate, and normoproteic, providing 200gr of animal protein. The treatment takes one month and can be extended up to two months. This combined therapy of hCG+very low-calorie diet, due to its action on fatty tissue inhibiting its synthesis, and due to its action on the hypothalamus, results in: Constant reduction of hyperglycemia) during the treatment period. Fast improvement of hypertriglyceridemia Reduction of high cholesterol levels. Stabilization of blood pressure to normal or acceptable levels. Marked reduction of total fat mass. A feeling of well being during the treatment period. Reduction of abdominal diameter.