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Circulating antigens of Schistosoma parasites in urine of schistosomiasis patients in Central Sudan

Abstract

Ashraf S. Yousif Eshtiyag A. Abdelkareem Salma M. Elhag Lemeis A. Elgimeaabi Magdi A. Ahmed Ehab A. Frah Ahmed Babiker Atif A. Elagib

This study was aimed to detect circulating antigens of the schistosoma parasites in urine of schistosomiasis patients living in two camps, Hababna and Elshajara camps within Tyieba Elshiekh Elgorashi village, located North West from Hassahiesa city in the Gezira state- central Sudan. The prevalence of S. haematobium in the two camps was 15.4% and the prevalence of S. mansoni was 53.8%. Urine samples of individuals infected with S. mansoni (93), S. haematobium (13) and with both (co-infection, 19), were electrophoretically separated on SDS-PAGE and immunoblotted against confirmed schistosoma patient’s serum. Immunogenic protein band with molecular weight 91 kDa was observed in all urine samples of individuals infected with S. haematobium and co-infection. In addition to 48 kDa in 8(61.5%), 11(57.9%) urine samples of infected individuals with S. haematobium and coinfection, respectively. A 60 kDa was found in 61(65.6%) urine samples of infected individuals with S. mansoni. No band was observed in urine samples of healthy control groups from endemic and nonendemic area. The present study showed that a 91 kDa protein is a highly immunogenic and may be a useful marker for diagnosing urinary schistosomiasis.

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