RANDRIAMAHAZO Rakotomalala Toky1 , JAONASOA Jean De La Croix1 , ANDRIANAPANALINARIVO Rakotovao Hery2 , RAKOTO ALSON Olivat1 , RASAMINDRAKOTROKA Andry1
Infection with hepatitis B virus (HBV) is a major worldwide public health problem; more than 2 billion people have been or are infected with this virus. Madagascar is classified by the WHO as a highly endemic country for HBV, with a chronic HBsAg carriage rate of more than 8% [1]. A study of pregnant women of Antananarivo has disclosed a rate of HbsAg prevalence estimated at 1.90 [2]. In Madagascar, no data is currently available regarding Hepatitis Delta (VHD) virus infection while the virus affects 5% of the chronic carriers, that is approximately 15 to 20 million people around the world. Our study aims at determining Hepatitis Delta prevalence for pregnant women, carriers of HbsAg who came for antenatal care at the Befelatanana obstetrics and gynecology teaching hospital department from February 2012 up to December 31, 2015.For any pregnant women who are positive for HbsAg, ELISA technique was used (Mediff® France) to seek Hbe antigen at the hospital’s lab while the antiHBe antibodies, HDV total antibodies and the HDVRNA have been explored at the National Reference Center pf Hepatitis Delta–Hôpitaux Universitaires Paris Seine-Saint-Denis France by using ELISA kit (Architect® Abbott, USA and Diasorin® Italy) and RT-PCR Eurobioplex HDV kit (Eurobio® France), respectively. All pregnant patients answered a questionnaire documenting their age, parity, personal
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