Biosimilar 2019 - Development of a male contraceptive from traditionally used Indian medicinal plants - Pratap Chand Mali - University of Rajasthan, India

Abstract

Pratap Chand Mali

And though millions of people have used condoms to control conception, 70 million unintended births occur worldwide. Therefore, there is an immediate need to take a fresh look at an appropriate method nowadays to test human fertility. Most plants such as Azardirachta, Crotalania, Tryptigium, Gossipium Hibiscus, Mikania, Quassia, Striga or its compounds have been tested for effective and reversible contraceptives in India , China and other parts of the world. In the present study, 50% Citrullus, Martynia and Maytenus ethanolic extracts were prepared and administered orally for 60 days at different doses in fertile, stable adult male rats with the goal of searching for a new safe, inexpensive, orally effective, reversible male contraceptive from conventional medicinal plants. Watermelons (Citrullus spp.) are prostrate, generally branched, gently hairy, deeply and roundly indented vines with blue-gray-green leaves and branched tendrils. It produces one flower per stem node. A male flower is formed at most nodes but at every seventh or eighth node, a female flower or hermaphroditic flower emerges. Modern cultivars are monoecious but they are andromonoecious like certain old cultivars. The bulbs are less showy than the melon and cucumber bulbs, becoming a little smaller and lighter pink. Watermelons need a long , warm growing season to mature, and are usually grown for fresh, edible fruit flesh consumption. Unlike melons and pumpkins, the consumed portion is the placental, or endocarp, area. Consumption of the seeds is also essential in some areas.