A case report on early stage orbital lymphoma in adults


Shatha Sofia Alaoui, Hicham Houda and Chalom Mustapha

Lymphoma is the most common malignancy of the orbit and the eyelids, accounting for 10% of malignant orbital tumors in adults. Orbital lymphomas can arise primarily in the orbit or represent a manifestation of disseminated disease. In this paper we report a case of early stage orbital lymphoma, which was managed successfully with chemotherapy, and a review of the related literature. A Moroccan Muslim woman aged 76 years, who presented a left orbital swelling. Ophthalmological examination complemented by CT has objectified orbital mass, whose biopsy was in favour of a non Hodgkin's lymphoma (NHL) large cell B. The patient was classified as stage IE after a record expansion. She was managed successfully with 6 courses of Rituximab 375 mg/m², Cyclophosphamide 750 mg/m² d1, Doxorubicine 50 mg/m² d1, Vincristine 1.4 mg/m² d1, and prednisone 50 mg/m² d1-5 (R-CHOP) regimen, with complete response. This case highlights the important role of R-CHOP regimen for achieving successful treatment cure for patients having an early stage orbital lymphoma


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