Study of the role of the rs2010963 polymorphism of the VEGFA gene in the formation of predisposition to immune microthrombovasculitis (Schönlein -Henochpurpura) in persons of Uzbek nationality

Abstract

D.S. Matkarimova

Genetic polymorphism rs2010963 of the VEGF gene has been detected in unrelated patients with immune microthrombovasculitis (Schönlein-Henoch purpura). A significant difference was found in the distribution of the G allele (p = 0.0003) and the C / G genotype (p = 0.0002) of the VEGFA gene (rs2010963) between the main group of patients with immune microthrombovasculitis and the control group. An assessment of the risk of developing the disease showed its association with the G allele (31.3% versus 13.7%; χ2 = 13.14; P = 0.0003; OR = 2.87; 95% CI 1.60-5.16) and the C / G genotype (χ2 = 13.8; P = 0.0002; OR = 3.85; 95% CI 1.86-7.98). Our results show that the polymorphism rs2010963 of the VEGFA gene is associated with the development of immune microthrombovasculitis in people of Uzbek nationality