Safety and Challenges of Scaffold used in Tissue Engineering

Abstract

PV. Mohanan

Tissue Engineering is a rapidly growing area having multidisciplinary science and expertise. This type of engineering has grabbed much attention may overcome the drawbacks involved within the current artificial organs and organ transplantation, as a replacement therapeutic means that have also aiming at lost or severely damaged tissues or organs. The Tissue Engineered Medical Products comprise the biological components such as the cells, tissue, cellular products, biomaterials, biologics or synthetic materials used in combination. Typically the cells are seeded onto a substrate and allowed to proliferate until an adequate amount of tissue or cells are available for transplant to the patient and the ‘device’ is generally considered as a combination product. In vitro and in vivo models to evaluate the safety or compatibility of the cellular materials are very specialized and specific. The evaluations include assessment of cytotoxicity, cell adhesion, growth and proliferation, expression of functional phenotype of the cells under consideration etc,