Histopathological study of prostatic lesions on needle biopsies with serum prostate-specific antigen (PSA)

Abstract

Rukhsana Akhter1, Ruby Reshi1, Zubair Ahmad Dar2* and Parvaiz Ahmad Dar2

Prostate develops from a series of endodermal buds from the lining of primitive urethra and the adjacent portion of urogenital sinus during the first 3 months of intra-uterine life. A prostate needle biopsy is a surgical procedure in which a small sample of tissue is removed from the prostate gland and examined under the microscope by a pathologist. In all investigated individuals, the level of prostatespecific antigen (PSA) was determined in identical way. PSA was estimated in venous blood by electrochemiluminescence method. Histopathological analysis of obtained material was done on standard hematoxylin-eosin (H&E) preparations. Out of 60 patients studied, most of the patients 30 (50%) were diagnosed with benign prostatic hyperplasia (BHP). Higher levels of PSA (>20) was found in 57.1% of patients of BHP with chronic prostatitis table 11. Out of the total number of adenocarcinoma patients, 77.8% of the patients were having preoperative PSA levels greater than 20. In our study, the positive predictive value for increasing PSA levels was 8.3% for PSA 4 ng/ml, 24.2% for PSA >10 ng/ml and 83.3% for PSA >100 ng/ml.