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Hypercalcemia secondary to parathyroid hormone secretion from metastatic lesions in liver

Abstract

Jennifer R. Dubay, Veena Patil, Neha Rickson, Anthony Morrison and David L. Vesely1

Parathyroid cancer is a rare malignancy with a prevalence of 0.005% of all registered cancer cases in the United States. Metastases are rare but when they occur the metastatic lesions are usually in the lungs and lymph nodes. There has been only one reported metastasis to the liver in the 233 combined year experience of several major medical centers. A 35-year-old man had 9 metastatic lesions in his liver which produced approximately 1500 mg/dl PTH and sustained hypercalcemia (12.3 mg/dl) even after surgical resection of the parathyroid cancer and a transient hypocalcemia.

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