Cytokines expression profiling as a window into hypoxia SH-SY5Y cells treated with N-butyl extract of Potentilla anserina L.

Abstract

Hong-Sheng Gao, Hui-Min Guo, Yi-Zheng Wang, Hong Chen, Yong-Liang Zhang , Ling-zhi Li and Jing Sun

Potentilla anserina L. is the root of Chinese cinquefoil herb of the Rosaceae family, and its ethanol extract improves the immunity and exhibits anti-fatigue and anti-hypoxia properties. This study aimed to explore the cytokines expression profiling and the effect of n-butanol extract of P. anserina L. (NP) on the hypoxia cells. The subjects were divided into three groups: control, hypoxia, and intervention (the group treated with the n-butyl extract of P. anserina L. under the condition of hypobaric hypoxia) groups. The results of the experiment showed that NP could down-regulate the expression of the proinflammatory cytokines of hypoxia SH-SY5Y cells and meantime up-regulate the expression of inhibitive cytokines of immune reaction. The cytokines expression profiling can be deduced as a window into hypoxia SH-SY5Y cells, and n-butyl extract of P. anserina L. can significantly protect the cell against the hypoxia induced damage set up in vitro by sodium dithionite.

PDF

Share this article

tempobet

tempobet giriş

tempobet giriş

bursa escort

tipobet e yeni giriş süpertotobet yeni giriş süperbahis 940 tipobet imajbet giriş yap imajbet giriş yap