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Comparative effects of Sorghum bicolor leaf base extract on tissues isolated from some body systems of experimental animals

Abstract

F. C. Nwinyi and H. O. Kwanashie

The knowledge of the effect(s) of substances to be used as medicines on different body systems is very vital in drug development vis-`a-vis drug safety. The effects of aqueous methanolic extract of Sorghum bicolor leaf base were tested on cardiovascular system-related in vitro models (such as isolated rat atria and rat portal vein), gastrointestinal system-related in vitro models (such as isolated rabbit jejunum, guinea pig ileum, rat stomach fundus strip) and reproductive system-related in vitro models (such as isolated rat uterus and rat vas deferens). The results showed that the extract did not alter the intrinsic myogenic contraction of both isolated rat atria and rat portal vein. The extract caused relaxation of rabbit jejunum and guinea pig ileum but contraction of rat stomach fundus strip. The extract did not alter the rhythmic contractions of stilboestrol pre-treated rat uteri. It, however, caused minimal contractions on the isolated rat vas deferens. The results of the studies therefore suggest that the extract may not have detrimental effect on the cardiovascular system if use as drug. The results also showed that the extract has the potential of being developed into antispasmodic and/or antimotility agent as a remedy for gastro-intestinal system related problems. Results also suggest that the extract may be non-uterogenic and may not be contraindicated in pregnancy. It may, however, have effect on the male reproductive secretary activity and ultimately, fertility.

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